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Causes measurable inflammatory and respiratory effects within minutes that can last for hours Increases childrens risk of sudden infant death syndrome, respiratory and ear infections, and asthma attacks Can create reproductive health problems, including low-birth-weight infants Increases adults risk of coronary artery disease, lung cancer, strokes, and premature death Has killed over two million people in the U.S
nAChRs are pentameric, assembling with various combinations of and nAChR subunits for a wide variety of nAChR subtypes with distinct pharmacokinetics, expression patterns, and actions on the cholinergic system (90, 91)
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Emphysema In an emphysema condition, the tobacco destroys the inner walls between the air sacs, causing the lungs air sacs (alveoli) to break down and creating bigger but fewer air sacs