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The FDA approved Ozempic for type 2 diabetes in 2017, and now new, potentially more potent and easier-to-produce versions are in the pipeline, says Susan Yanovski, a physician and nutrition specialist at the National Institute of Diabetes and Digestive and Kidney Diseases in Bethesda, Md

However, the drug's significant physiological effectsparticularly the potential for severe urine dilution from increased water intakecan create conditions where a false negative is more likely to occur

2.4 mg once weekly is the labeled maximum for weight management

A phase 3 trial of semaglutide for NASH-related fibrosis (ESSENCE trial) is underway

Li D, Taniguchi EV, Cai S, Paschalis EI, Wang H, Miller JB et al