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Tobacco use continues to be one of Canada's most significant public health problems, and is the country's leading preventable cause of disease and premature death in Canada, said Jean-Yves Duclos, Canadas Minister of Health, in the announcement

With respect to cytotoxicity, a dose response was reported and it was suggested that the nicotine level in the saliva of smokeless tobacco users may be high enough to achieve cytotoxicity

We believe these assays are a more relevant replacement for in vivo animal testing.

16 in the journal The Lancet found no statistically significant difference in the merits of the e-cigarette over the nicotine patch in terms of helping people quit