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The natural signaling molecule for nAChRs is acetylcholine, which nicotine can imitate as it binds to these receptors
These effects were markedly attenuated in KPC mice given metformin, which prevented nicotine-induced pancreatic carcinogenesis and tumor growth by up-regulating GATA6 and promoting differentiation toward an acinar cell program (50)
Cigarettes had been widely used in the United States for decades before conclusive evidence of the link between their use and premature death from cancer and cardiac events was established in the 1950s and early 1960s
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