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Orlistat improved cholesterol, blood pressure, and diabetes risk but caused gastrointestinal issues, sibutramine improved lipids, and rimonabant enhanced cardiovascular markers but increased mood disorder risk

While these medications can lead to significant weight loss, there are questions about how to combat side effects such as loss of muscle mass

[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Jensen S.B.K., Blond M.B., Sandsdal R.M., Olsen L.M., Juhl C.R., Lundgren J.R., et al

The CagriSema versus tirzepatide comparison is particularly interesting because both achieve similar weight loss magnitudes through completely different receptor combinations