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In summary, human SAM studies indicate that hepatic steatosis is associated with epigenetic dysregulation of metabolic and signaling pathways, whereas animal models reveal transcriptional reprogramming involving peroxisome loss, stress responses, and disrupted mitochondrial function

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In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation

Higher IL-6 levels were measured in NS workers compared to DS, implicating NSW in immune dysregulation 148