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ND heritability is enriched for genes expressed in cerebellum To assess whether heritability of ND is enriched in regions surrounding genes with the highest specific expression patterns in given tissue/cell type(s), we applied LDSC-SEG 44 using the EUR-specific ND GWAS meta-analysis results with reference to 205 tissues/cell types with publicly available gene expression data assembled from GTEx 45 (53 human tissues/cell types) and the underlying data that is used to comprise the Data-driven Expression Prioritized Integration for Complex Traits (DEPICT) tool 46,47 (152 tissues/cell types from humans and rodent models)

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Of the 2,149 smokers enrolled in the study, 1,901 individuals completed it

Homocysteine, a blood chemical detrimental to blood arteries, circulates in higher amounts due to smoking