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Representative images of H&E staining of fetal liver cells from E12.5 Slc25a39 fl/fl and Ergfpcre +/- Slc25a39 fl/fl embryos

Several factors can lead to hyperpigmentation: Sun exposure: UV radiation stimulates melanin production, leading to dark spots, often called sunspots or age spots

The supplements are generally well-tolerated at doses up to 500 mg daily for up to 2 months

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BOX 7-1 Lesion Characteristics in Nails That Should Raise a Red Flag Location: Single digit, thumb, or great toe nails Appearance: Fast growth, longitudinal melanonychia, band width more than 3-5 mm Hutchinsons Sign: Periungual pigmentation of skin Nail Dystrophy: Notch in free distal nail margin, surface irregularity, oozing, or bleeding lesion similar to ingrown nail Melanonychia striata Brown longitudinal stria (plural is striae) that occurs in the nail is called melanonychia striata