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As a lipid-soluble antioxidant, vitamin E: Embeds itself in cell membranes and lipoproteins to prevent lipid peroxidation Breaks chain reactions of free radical damage in fatty tissues Protects polyunsaturated fatty acids (PUFAs) from oxidation Works synergistically with selenium and vitamin C Vitamin E's effectiveness is limited to lipid environments, and it requires vitamin C to regenerate after neutralizing free radicals