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Cigarettes and cancer Tobacco smoke is widely considered the greatest preventable cause of cancer, causing up to 1.5 million cancer deaths worldwide every year, according to the World Health Organization

In 2012, Falls Church City, VA had the lowest prevalence at 9.9% (8.1%-12.0%), while the highest prevalence was still found in Northwest Arctic Borough, AK at 41.5% (35.9%-46.8%), a 31.7 percentage point difference

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Chromatin condensation evaluation: chromomycin A3 (CMA3) staining The CMA 3 staining was used to detect the abnormal protamination as described by Manicardi et al., 1995