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Sustaining the engine: mitochondrial quality control and transport networks As the central engine of cellular bioenergetics and intermediary metabolism, mitochondrial functional integrity is critical for sustaining high metabolic flux, anabolic potential, and therapeutic responsiveness in CRC [18]

Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria

GSH conjugation (followed by secretion from the cell) may be either spontaneous or catalyzed by one of several enzymes, including the GSH-transferases (GSTs), which have wide substrate diversity

295 Excessive mutHTT can overwhelm the UPS, dysregulating proteostasis and further promoting mutHTT accumulation