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--- The Clinical Frontier The strongest human evidence now supports: Metformin (metabolic reprogramming) NAD boosters (mitochondrial repair) MSC infusions & TPE (cellular rejuvenation) GLP-1 agonists (metabolic efficiency) The future lies in combination strategies integrating metabolism, cellular repair, and mitochondrial support for multimodal rejuvenation

Triggers of IL-1 production have been observed in a number of different stimuli, such as sulfur mustard, nickel, contact allergens or superantigens 36 IL-1 stimulates further release of secondary mediators, including IL-8

A., & Vannella, K

10.1016/j.redox.2020.101799 Izzotti A, Bagnis A, Sacc SC: The role of oxidative stress in glaucoma

Adequate sleep is also crucial, as glutathione production and recycling occur during rest periods