Progressive hypotension was described following a second intravenous injection in some cases
Inhibition of IL-1, IL-6, and TNF- release from macrophages, iNOS expression and subsequent NO production, prostaglandin production, cyclooxygenase (COX) enzyme activity, apoptosis, and MPO activity are the potential mechanisms by which RSV exerts its anti-inflammatory effect (90, 91) ( Supplementary Table 1 )
Consistently, they reduce DHA into ascorbate with a better efficiency ( k cat around 10 4 s 1 , k cat / K m around 10 7 M 1 .s 1 ) compared to the other enzymes ( k cat around 10 2 s 1 ) and to the reduction of glutathionylated-mercaptoethanol, the product formed upon incubation between GSH and HED ( k cat around 10 2 s 1 ) (Table 5) (Dixon et al., 2003)
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Funding: This work was supported by grants from Associazione Italiana Ricerca sul Cancro (AIRC) (www.airc.it) to M.G.P., Ministero della Salute (www.ministerosalute.it) grants to M.G.P., V.M
