2024 perioperative management glp-1 receptor agonists anesthesia How should we approach patients on agonists? Check out this excellent editorial from Dr. Girish Joshi, "Clarifying the Guidelines and Decoding the Enigma: Strategies for Anesthetic of Patients on Glucagon-Like GLP-1 receptor agonists and surgical

28: The lancet 344 :796-798,1994 29: Nutrition reviews 54 :1-30,1996 30: clinical science 91 :575-582, 1996 31: Clinical science 91 :575-582, 1996 32: Hong SY, Gil HW, Yang JO, Lee EY, Kim HK, Kim SH, Chung YH, Hwang SK, Lee ZW (2005)

One obstacle has been poor survival and integration of grafted DA neurons [85]

65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.231.52])

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Clinical implication The updated FDA labeling for liraglutide and semaglutide highlights the importance of monitoring depressive symptoms or suicidal thoughts, suggesting treatment discontinuation if such ideations occur [87,88]