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These findings suggest that the effects of SGLT2 inhibitors extend beyond hemodynamic improvements, involving direct modulation of intracellular pathways implicated in kidney injury

doi: 10.1002/1098-1128(200103)21:2 3.0.co;2-u

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Patients and clinicians should weigh whole-person outcomes, monitor mood, and adjust therapy as needed while research continues to clarify these brainbody connections.