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Reich, T., Adato, O., Kofman, N

Accessed October 9, 2025

Over 72 weeks, the 15 mg dose delivered a mean weight reduction of about 20.9%, and the 10 mg dose about 19.5%

However, alterations in the gut microbiome can influence the bile acid synthesis rate, potentially leading to increased plasma levels of LDL cholesterol and an elevated risk of atherosclerosis (196)