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It acts prominently on nitric oxide (NO) signaling , counteracting the damaging effects of NO inhibition (e.g., L-NAME) and modulating eNOS through the upregulation of antioxidant enzymes (e.g., HO-1)

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Indeed, they also demonstrated that PQ plus maneb induces ferroptosis in SH-SY5Y cells (Hou et al., 2019a) and that this can be suppressed by ferrostatin-1, liproxstatin-1, or deferoxamine (Hou et al., 2019a)