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16 17 18 Newly emerging indications for GLP-1 medicationsincluding heart disease, metabolic liver disease, peripheral artery disease, Alzheimers/dementia risk, and even alcohol and substance use disorders, as highlighted in a 2025 study in JAMA 19 suggest these drugs may soon play a much broader role in medicine than just treating diabetes or obesity

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While PDE5 inhibitors are effective for many patients, some men experience inadequate response or persistent low libido, prompting increased clinical interest in centrally acting therapies such as PT-141

Kim J, Parish AL