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SAMe is an internally produced compound found in every cell of the human body that is involved in more than 100 biochemical reactions

The liver can export vitamin E in very low density lipoproteins (VLDLs)

Mol Pharmacol 65:5507, PMID: 14978233 Coles BF, Kadlubar FF (2003) Detoxification of electrophilic compounds by glutathione S -transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs

Furthermore, studies have found that verapamil can enhance the neuroprotective effect of berberine by inhibiting the mechanism of P-glycoprotein efflux and preventing changes in calcium homeostasis (Kumar et al., 2016)

However, factors such as poor diet, excessive alcohol consumption, and exposure to environmental toxins can overwhelm the livers capacity to detoxify effectively