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It can be associated with the lack of B12 and iron deficiencies

In experiments where electrical stimuli were directly applied to the surface of the cerebellar cortex but also at various depths below the surface, John Eccles and a group of pioneering cerebellar electrophysiologists (1966) observed an excitatory response that propagated along the parallel fibers and was flanked on either side by inhibitory responses [309]

The choice comes down to personal preference regarding convenience versus flexibility and cost

doi: 10.1016/j.molstruc.2013.01.049

This impairment can lead to issues such as irregular menstrual cycles in women