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Ive used them myself following a shoulder labral repair, and it cut my recovery short by 3 weeks

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Never inject into areas of active bruising, redness, or hardness from previous injections

Rahman MH, Jeong ES, You HS, Kim CS, Lee KJ

Reactions to sulfa drugs can be quite severe including anaphylaxis and Stevens-Johnson syndrome (a life-threatening skin reaction), but more commonly seen are less severe reactions such as fever or rash occurring 1-2 weeks after exposure