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For example, individuals with NAFLD exhibit increased intestinal permeability and prevalence of small intestine bacterial overgrowth, and these factors are associated with the severity of hepatic steatosis 19

These findings are specific to controlled animal models and are used to better understand how NNMT and related pathways influence energy storage and utilization, not to support clinical or therapeutic conclusions

B., Ciccolini, K., Donati, A

When combined with an increased concentration of carnitine in urine, the suspicion of SPCD can often be confirmed by either molecular testing or functional studies assessing the uptake of carnitine in cultured fibroblasts