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The interactions generated by the STRING are based on the known interactions (from the curated databases and experimentally determined), predicted interactions (e.g., gene neighborhood and gene co-occurrence) as well as few other factors viz

doi: 10.1007/s00417-011-1844-0

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Nonetheless, the same mechanismsparticularly delayed gastric emptying and central satiety signalsalso underlie a wide spectrum of GI side effects, ranging from mild and transient symptoms to clinically significant complications such as gastroparesis and acute pancreatitis