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The final part of this group is the thioredoxin (Trx) system, another thiol-based redox mechanism that is independent of GSH

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Other constituents, such as vinyl chloride, have a well-established association with hepatic angiosarcoma [28], whereas cadmium enhances liver cancer risk through proto-oncogene activation, oxidative stress induction, and stimulation of pro-inflammatory cytokines [29,30,31]