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Genetic Variations (GSTM1, GSTP1 Polymorphisms) Polymorphisms in genes encoding glutathione S-transferases (GSTs) can reduce detoxification capacity and glutathione efficiency by 20-40%

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10.1038/s41574-018-0059-4 Nat Rev Endocrinol

Thus, DNTB method grants measurement of free GSH, oxidized GSH (GSSG) and total content of GSH (free GSH + GSSG) in a multi-step approach in biological samples

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