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[1] [2] The pivotal SUSTAIN trials, which evaluated semaglutide for type 2 diabetes, and the STEP trials for weight management did not identify cold intolerance as a statistically significant adverse event

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The FDA approved Ozempic (semaglutide) tablets (formerly marketed as the Rybelsus R2 formulation) in February 2026

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Hypoglycemia, which can impair cognition, is uncommon with GLP-1 monotherapy but risk increases when combined with insulin or sulfonylureas