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NICE recommends duloxetine as first-line treatment for painful diabetic neuropathy if symptomatic relief is needed

It also aids in the regeneration of damaged nerve tissues, making it a preferred choice for treating peripheral neuropathy and weakness associated with B12 deficiency

doi:10.3389/fendo.2020.00191 63

Another meta-analysis of 21 trials in overweight and obese individuals found small but significant reductions in body weight (approximately 0.75 kg), BMI, and body fat percentage compared to placebo