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The catalytic subunit of GCL is subject to competitive feedback inhibition by glutathione, thus preventing an excess of glutathione production (Richman and Meister 1975)

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Additionally, its potent antioxidant properties neutralize free radicals, thereby combating premature aging and promoting a youthful complexion

Thus, in addition to simply acting as a sedative agent, dexmedetomidine seems to treat the underlying pathophysiology (serotonin excess)

But available pharmacokinetic data and animal studies provide valuable insights into relative efficacy between administration methods