558 Mice with GPX4 conditional knockout in forebrain neurons (GPX4BIKO mice) exhibited notable impairments in spatial learning and memory
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The time lapse contains examples (white arrowheads) of microglia (green) comprising honeycomb networks that collapse and immediately fill the holes in their network likely as a result of astrocyte cell death in the glial limitans
This similarity suggests that the altered energy metabolism at baseline observed in ME/CFS may compromise the ability of these patients to respond to exercise in the same way as healthy individuals
However, joints are also sites where oxidative stress can accumulate, especially after intense physical activity
