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Intriguingly, one of these studies also showed that longer administrations can lead to a normalization of anxiety and a dissociable improvement in depression-like behavior 158 a pattern that resembles of the mechanisms of action of conventional antidepressants and that may be further suggestive of the activity of GLP-1RAs on the serotonin system 158

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Pancreatitis is a rare but serious adverse event reported with GLP-1 agonists

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In TriNetX, propensity score matching is performed using observed baseline covariates, such that patients without documented laboratory values (eg, hemoglobin A1c or body mass index) are excluded from the matched cohorts in favor of individuals with available data