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Individuals taking metformin alongside Mounjaro face higher B12 deficiency risk and may require more frequent monitoring

After the translation of IGF - IR mRNA, the 210 kDa protein product (pro-IGF-IR) is subject to endoproteolytic cleavage by the pro-protein convertases such as furin and pro-protein convertase 5, leading to the generation of chain (706 amino acids) and chain (627 amino acids) [22]

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In particular, the NLRP3 inflammasome is one of the five major inflammosomes that induces secretion of IL-1 (Elliott and Sutterwala, 2015)