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Although corticosteroids were considered as the first intralesional medication in PD, early published studies, including retrospective analyses and RCTs, have had mixed findings (Lamprakopoulos et al., 2000)

Moreover, B12 is critical for synthesizing neurotransmitters chemical messengers such as dopamine and serotonin that regulate mood and stress response

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Agents that provide benefits beyond glucose lowering - such as reducing heart disease risk - are rewarded with broader guideline adoption and wider clinical utilization

These mechanisms can trigger headaches through several pathways: rapid changes in blood glucose levels, shifts in fluid and electrolyte balance due to reduced food intake, and activation of GLP-1 receptors in blood vessels and the nervous system