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GLP-1 agents do not directly modulate estrogen, but their appetite-suppression and insulin-sensitizing effects address the metabolic consequences of estrogen withdrawal

Glycemic Control: advantage goes to Orforglipron

Sarah, 35 Gradual Weight Loss Protocol: 0.25 mg 0.5 mg in Week 9 Results: 11 lbs over 16 weeks, minimal nausea

It may change hormone levels, brain chemicals, energy, mood, and how people feel about themselves

Liver Enzymes In a pediatric clinical trial, increases in alanine aminotransferase (ALT) greater than or equal to 5 times the upper limit of normal were observed in 4 (3%) WEGOVY-treated patients compared with 0% of placebo-treated patients