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After obtaining written informed consent, 64 patients of dermal type of malar melasma, examined by wood's lamp and dermoscopy, were included

In 2011, 70% of the procedures involved chondroplasty (smoothing the defect by removing loose strands of cartilage), 28% involved microfracture or subchondral drilling (techniques used to release marrow elements), and only 2% involved the use of advanced cartilage restoration techniques (osteochondral autograft transfer, ACI)

This pattern suggests the peptide addresses underlying tissue health rather than masking dysfunction through unrelated pathways

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