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In clinical observation, reports of excessive thirst, frequent urination, or lethargy after meals can be early indicators of declining insulin sensitivity and should prompt a re-evaluation of the protocol

However, there was a slight improvement in the DPS and PHP-DPS NPs treatment groups, with further decrease after INS treatment

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Relative GSH/GSSG ratios were mostly unchanged in non-stimulated cells except for the Nlrp3 / cells that presented increased ratios (Fig

Individuals were excluded if they had clinically significant abnormalities on electrocardiogram, physical examination or laboratory analyses