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These findings have positioned GLP-1s as a preferred second-line treatment option after metformin, particularly in patients with established heart disease

Notably, the reductions observed in these parameters were greater than those seen with semaglutide 1 mg, another GLP-1 receptor agonist, in the SUPRASS-2 trial.Tirzepatide was generally well-tolerated, with a low risk of hypoglycaemia when used without insulin or insulin secretagogues

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Better versions of GLP-1s emerge which are more effective, cheaper, easier to take