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Several decades later, researchers noticed that the effects of GLP-1 are markedly reduced in people with Type 2 diabetes

In 90-day tests, whether given through the diet (up to 9375 mg/kg BW/day) or by intramuscular injection (up to 0.5 ml/kg/day) in rabbits, no significant signs of toxicity were observed

Beyond a certain threshold, higher doses don't produce additional benefits and may actually reduce effectiveness through receptor desensitization

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The medication may further reduce absorption of the small amounts obtained from fortified foods