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Clinical Evidence In a 2021 clinical trial (SURPASS-2), tirzepatide was found to have greater reductions in hemoglobin A1c (HbA1c) and body weight than semaglutide 1 mg in people with type 2 diabetes [6]

reported the kinetics of the two different GDH forms from the bovine brain (bGDH1 and bGDH2) ( GDH in brain development Since glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS), mitochondrial function and glutamate metabolism are closely related in the brain ( Target neurons are depolarized by glutamate produced by active synapses via certain receptors (Mayer et al., 1984

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doi: 10.1371/journal.pone.0049062 86