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Keywords: type 2 diabetes, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide Introduction: The Incretin Effect in Health and Disease The gastrointestinal system has an intricate pathway of hormones that are released from the gut lining upon ingestion of food and regulate glucose metabolism and appetite

These numbers raise the possibility that retatrutide could achieve weight loss comparable to bariatric surgery, but without the need for an operation

Furthermore, emerging studies explore its combined effects with GLP-1 receptor agonists in controlled models

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