In clinical trials of semaglutide for type 2 diabetes mellitus, patients exposed to semaglutide subcutaneous injection reported increases in amylase (hyperamylasemia) and lipase, and had a mean increase from baseline in amylase of 13% and lipase of 22%
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After replacement she rapidly felt better and regained several kilos over the next months
However, systemic effects from distant-site injection are also documented, and for diffuse neuropathies affecting multiple nerve territories, systemic administration may provide more uniform coverage
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