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Higher GABA activity in the brainstem can reduce the sensitivity of the area postrema to nausea triggers, effectively raising the threshold for how much GLP-1 stimulation is needed before nausea occurs

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This difference impacts how the drugs work in the body and their effectiveness in weight loss and glucose regulation

42 Likewise, a systematic review of 41 studies involving overweight or obese participants showed a significant reduction in total-hip BMD (0.0100.015 g/cm 2 ) after weight-loss interventions lasting six months or longer, whereas lumbar-spine BMD remained stable

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