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Weight loss during this period is typically 2 to 4 pounds, primarily from reduced caloric intake and initial fluid shifts

Ten deaths (1%) on tirzepatide and 12 (1%) on glargine were adjudicated as undetermined, and thus considered cardiovascular deaths for MACE determination

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Authors reported small statistically significant differences in weekly weight loss at the 1 mg dose with a non-linear dose response, but the abstract data has not been published in full peer-reviewed form