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(2017) assessed 8-iso-PGF2 across 50 human health conditions, revealing that diseases such as cystic fibrosis (g = 2.3), pulmonary arterial hypertension, and chronic renal insufficiency (g = 1.9) demonstrated stronger associations with oxidative stress than traditional cardiovascular risks like hypertension (g = 0.4) or metabolic syndrome (g = 0.5)