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These reagents were added either in Cys 2 -free culture medium or coincubated with BSO or erastin at indicated concentrations

Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone , and side-chain 1 and 2 dihedral angles

High homocysteine concentrations may promote the development of atherosclerosis (atherogenesis) and thrombogenesis via mechanisms involving oxidative stress and endothelial dysfunction, inflammation, abnormal blood coagulation, and disordered lipid metabolism (reviewed in 35)

The important issue of comorbidities of gout is discussed in more detail in Who Gets Gout

Fiber reduces mechanical stress