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Hormonal disruption

Emerging studies (e.g., STEP trials, 2021) note potential for sustained effects through slowed gastric emptying and reduced glucagon

The dual mechanism produces additive or combined effects on energy balance -- GIPR activation in the CNS may enhance the anorectic signals from GLP-1R activation, and peripheral GIPR signaling improves adipose tissue function and lipid handling in ways GLP-1 alone does not

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