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GPX4 inhibition enhances glioma radiosensitivity by inducing oxidative stress-dependent SSG and degradation of transglutaminase 2 (TGM2), impairing DNA repair 126

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However, hypoglycemia risk increases when these agents are combined with insulin or insulin secretagogues, necessitating dose adjustments of concomitant medications in many cases

Asian Pacific J Cancer Prevent: APJCP 17(11):4929 Abe R, Ohtani K (2013) An ethnobotanical study of medicinal plants and traditional therapies on Batan Island, the Philippines