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Participants who had not lost at least 5% of their starting body weight by week 12 rarely achieved robust results by week 48

That is because it appears to affect insulin sensitivity and glucose metabolism rather than acting like a GLP-1 receptor agonist

This is to ensure that the control is robust against perturbation in terms of frequency being not perfectly measureable

Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials

Acknowledgments We are grateful to all participants and acknowledge the support of the members of the RECAP study who contributed considerably to data collection