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He draws parallels to alcohol metabolism, where acetaldehyde causes more harm than the alcohol itself, and explains that methanol's toxicity comes from its conversion to formaldehyde (which is why wood alcohol -- methanol -- makes people blind and should not be consumed)

these benefits disappear with AMPK inhibition (Zhang et al., 2020)

References Cerovecki, T., Bojanic, I., Brcic, L., Radic, B., Vukoja, I., Seiwerth, S., & Sikiric, P

Metabolism and longevity: Is there a role for membrane fatty acids

Thus, the crucial equilibrium between ROS production and antioxidant reserve is vital to ensure cellular redox homeostasis and general well-being [29]