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Recent studies suggested that mitochondrial DNA damage is also a potential biomarker in LRRK2-PD ( LRRK2 is an enzyme with both kinase and GTPase activities (Steger et al., 2016), which are important for exocytosis of synaptic vesicles, and endolysosomal and Golgi apparatus protein sorting (West et al., 2005

CMI, Chronic multisymptomatic Illness

Early identification is essential, as progressive weight regain can lead to recurrence of type 2 diabetes, hypertension, obstructive sleep apnea, and other obesity-related conditions that had previously improved or resolved

Levels drop significantly with age