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How to eat, think, live and most importantly, how to change your relationship with food, she writes

A causative role for estrogen in the expression of lipedema remains speculative until well-controlled studies are conducted that quantify sex hormone levels, sex hormone receptors, tissue effects, metabolism or sex hormone driven pathways in men and women with lipedema

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2.9 Statistical analysis All MR analyses were performed using the TwoSampleMR package in R (version 4.3.0)